Anti-Human TRAIL-R2 Recombinant Antibody (TAB-196)
CAT#: TAB-196
Recombinant monoclonal antibody to TRAIL-R2. It is a monoclonal antibody for the treatment of cancer.
Gene Expression
Tested Data
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51170_B_7_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_3.jpg
Normal Tissue
Figure 3 Liver
Cholangiocytes
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_6_6.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_8.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120889-TNFRSF10B
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SDS-PAGE
Figure 1 Anti-Human TRAIL-R2 Recombinant Antibody (TAB-196) in SDS-PAGE
SDS-PAGE analysis of TAB-196 in reduced (Lane 1) and non-reduced (Lane 2) conditions. Gel stained for 30 minutes with Coomassie Blue. As a result, different β-mercaptoethanol-reduced proteins (Heavy chain and Light chain) migrate as about 50 kDa and 25 kDa, respectively.
The purity of TAB-196 was greater than 95% as determined by SDS-PAGE.
SEC-HPLC
Figure 2 Anti-Human TRAIL-R2 Recombinant Antibody (TAB-196) in HPLC
The purity of TAB-196 was greater than 95% as determined by SEC-HPLC.
WB
Figure 3 Anti-Human TRAIL-R2 Recombinant Antibody (TAB-196) in WB
Western blot analysis of TAB-196 was performed by loading Recombinant Human TRAIL-R2.
TAB-196 incubation concentration: 2 ng/μL.
The secondary antibody: HRP-anti-human IgG
Lane 1: Reducing Antigen (0.1 μg)
Lane 2: Reducing Antigen (0.3 μg)
Lane 3: Reducing Antigen (0.6 μg)
ELISA
Figure 4 Anti-Human TRAIL-R2 Recombinant Antibody (TAB-196) in ELISA
ELISA analysis of TAB-196 was performed by coating with Recombinant Human TRAIL-R2.
The secondary antibody: HRP-anti-human IgG
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Derivation
- Humanized (from mouse)
- Type
- IgG1
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- IF, IP, Neut, FuncS, ELISA, FC, ICC
- MW
- 144.6 kDa
- Related Disease
- Unknown
Product Property
- Purity
- >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The TNFRSF10B antibody has been reported in applications of WB, Inhib, FC, IHC.
Target
- Alternative Names
- Tigatuzumab;918127-53-4;CS-1008;TRA-8;CS-1008;TNFRSF10B;tumor necrosis factor receptor superfamily, member 10b;tumor necrosis factor receptor superfamily member 10B;CD262;DR5;KILLER;TRAIL R2;TRICK2A;TRICKB;Fas-like protein;death receptor 5;cytotoxic TRAIL
- Gene ID
- 8795
- UniProt ID
- O14763
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Biosimilar Overview
Please refer to Tigatuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Tigatuzumab.
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-0703-YJ-VHH | Camelid Anti-TNFRSF10B Recombinant Single Domain Antibody (HPAB-0703-YJ-VHH) | ELISA, Apop | Camelid VHH |
| HPAB-0704-YJ-VHH | Camelid Anti-TNFRSF10B Recombinant Single Domain Antibody (HPAB-0704-YJ-VHH) | ELISA | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-203 | Human Anti-TNFRSF10B Recombinant Antibody (TAB-203) | ELISA, IP, FC, FuncS, Neut, IF, ICC | Human IgG1, κ |
| TAB-195 | Anti-Human TRAIL-R2 Recombinant Antibody (TAB-195) | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - lambda |
| TAB-180 | Anti-Human DR5 Recombinant Antibody (TAB-180) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - lambda |
| TAB-253MZ-S(P) | Anti-Human TNFRSF10B Recombinant Antibody scFv Fragment (AU11) | FC, ELISA | Human antibody |
| TAB-254MZ-S(P) | Anti-Human TNFRSF10B Recombinant Antibody scFv Fragment (AU12) | FC, ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-625CL | Human Anti-TNFRSF10B Recombinant Antibody (TAB-625CL) | ELISA | Single Domain Antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBW-057 | Human Anti-TNFRSF10B Recombinant Antibody (clone YSd1); Fab Fragment | ELISA | Human Fab |
| HPAB-M0231-YC-F(E) | Human Anti-TNFRSF10B Recombinant Antibody (clone TR2-3); Fab Fragment | ELISA, WB | Human Fab |
| HPAB-N0268-YC-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (HPAB-N0268-YC-F(E)) | FC, Inhib | Humanized Fab |
| HPAB-0416-YJ-F(E) | Mouse Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (HPAB-0416-YJ-F(E)) | ELISA, FuncS | Mouse Fab |
| HPAB-0417-YJ-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (HPAB-0417-YJ-F(E)) | ELISA, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-247MZ | Mouse Anti-TNFRSF10B Recombinant Antibody (TAB-247MZ) | ELISA, FC, FuncS, Inhib | Mouse IgG3, κ |
| TAB-247MZ-S(P) | Mouse Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-247MZ-S(P)) | ELISA, WB | Mouse scFv |
| TAB-248MZ-S(P) | Mouse Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-248MZ-S(P)) | FC, ELISA | Mouse scFv |
| TAB-249MZ-S(P) | Mouse Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-249MZ-S(P)) | FC, ELISA | Mouse scFv |
| TAB-252MZ-S(P) | Anti-Human TNFRSF10B Recombinant Antibody scFv Fragment | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-250MZ | Human Anti-TNFRSF10B Recombinant Antibody (TAB-250MZ) | FuncS | Humanized IgG |
| TAB-251MZ | Human Anti-TNFRSF10B Recombinant Antibody (TAB-251MZ) | FuncS | Humanized IgG |
| TAB-250MZ-S(P) | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-250MZ-S(P)) | FC, ELISA | Humanized scFv |
| TAB-250MZ-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (TAB-250MZ-F(E)) | FC, ELISA | Humanized Fab |
| TAB-251MZ-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (TAB-251MZ-F(E)) | FC, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3604 | Rabbit Anti-TNFRSF10B Recombinant Antibody (clone DS3604AB), PE | FC, WB | Rabbit IgG |
| MOR-3605 | Rabbit Anti-Tnfrsf10b Recombinant Antibody (clone DS3605AB) | ELISA | Rabbit IgG |
| MOR-4468 | Rabbit Anti-Tnfrsf10b Recombinant Antibody (clone SI562DS) | ELISA | Rabbit IgG |
| MOR-4469 | Rabbit Anti-TNFRSF10B Recombinant Antibody (clone SI563DS) | ELISA, FC | Rabbit IgG |
| MOR-4473 | Rabbit Anti-TNFRSF10B Recombinant Antibody (clone SI567DS) | FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-104LC | Human Anti-TNFRSF10B Recombinant Antibody (MOB-104LC) | FuncS | Chimeric (mouse/human) IgG1, κ |
| VS-0724-XY43 | Mouse Anti-TNFRSF10B Agonistic Antibody (VS-0724-XY43) | Agonistic assays | Mouse IgG1 |
| VS-0724-XY44 | Mouse Anti-TNFRSF10B Agonistic Antibody (clone B-D37) | ELISA, FC, FuncS, IP | Mouse IgG2b, kappa |
| VS-0724-XY60 | Human Anti-TNFRSF10B Agonistic Antibody (clone AMG 655) | ELISA, Agonistic assays | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0303-YC-S(P) | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (HPAB-0303-YC-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-0304-YC-S(P) | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (HPAB-0304-YC-S(P)) | FuncS | Human scFv |
| HPAB-1145WJ-S(P) | Mouse Anti-TNFRSF10B Recombinant Antibody (clone E-11-13); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-1146WJ-S(P) | Mouse Anti-TNFRSF10B Recombinant Antibody (clone L-30-10); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-1147WJ-S(P) | Mouse Anti-TNFRSF10B Recombinant Antibody (clone H-48-2); scFv Fragment | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0494-CN | Rabbit Anti-TNFRSF10B Recombinant Antibody (clone JA03-38) | WB, IP, IHC, FC | Rabbit IgG |
| FN-054CQ | Mouse Anti-TNFRSF10B Recombinant Antibody (clone HS201) | FC, Inhib, ICC, IP | Mouse IgG1 |
| HPAB-1180WJ | Human Anti-TNFRSF10B Recombinant Antibody (clone TRA-8) | Cyt, IF, Inhib, WB, ELISA, FC | Humanized IgG |
| HPAB-0672YY | Human Anti-TNFRSF10B Recombinant Antibody (HPAB-0672YY) | ELISA, FuncS | Humanized IgG1 |
| VS7-0425-WR1010 | Mouse Anti-TNFRSF10B Recombinant Antibody (clone 2H5B8) | WB, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-196 | Afuco™ Anti-TNFRSF10B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-196) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-203 | Afuco™ Anti-TNFRSF10B Recombinant Antibody (AFC-TAB-203), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | Human IgG1, κ |
| AFC-TAB-180 | Afuco™ Anti-TNFRSF10B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-180) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-195 | Afuco™ Anti-TNFRSF10B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-195) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY72 | Human Anti-TNFRSF10B (clone Lexatumumab) scFv-Fc Chimera | ELISA, IP, FC, FuncS, Neut, IF, ADCC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC222 | Recombinant Anti-TNFRSF10B Vesicular Antibody, EV Displayed (VS-0425-YC222) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7361 | Anti-Mouse TNFRSF10B Immunohistochemistry Kit | IHC | |
| VS-0525-XY7362 | Anti-Monkey TNFRSF10B Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC232 | Recombinant Anti-TNFRSF10B (ECD x DD) Biparatopic Antibody, Tandem scFv | ELISA, FC, ICC, IF, IP, Neut | Tandem scFv |
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